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Monitor Intently (one)pentobarbital will minimize the level or influence of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to the lessen in fentanyl plasma concentrations, not enough efficacy or, quite possibly, enhancement of a